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Generic Zoloft Zoloft is usually prescribed for depressive disorders such as persistently low mood that interferes with everyday living. It is currently the #1 doctor-prescribed brand of its kind. Zoloft has treated millions of people with more types of depression and anxiety than any brand of its kind for over 12 years.

Zoloft is a member of the family of drugs called "selective serotonin re-uptake inhibitors." Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Zoloft slows this process, thereby boosting the levels of serotonin available in the brain.